Anti-seizure medications (ASMs): choice with childhood seizures
Evidence-based neurology checklist on anti-seizure medications (asms): choice with childhood seizures: Absence seizures: Level A and C evidence Ethosuximide first line Valproate especially if high risk of generalised tonic clonic seizures Lamotrigine only if above are not possible Lamotrigine:…
Absence seizures: Level A and C evidence
- Ethosuximide first line
- Valproate especially if high risk of generalised tonic clonic seizures
- Lamotrigine only if above are not possible
- Lamotrigine: Level C evidence
Absence seizures: drugs that may worsen absences
Generalized tonic clonic seizures: Level C and D evidence
Partial-onset seizures: Level A and C evidence
Partial-onset seizures: Level D evidence
BECTS: Level C and D evidence
Drug combinations to avoid
Acronym
References
- Glauser T, Ben-Menachem E, Bourgeois B, et al; ILAE Subcommission on AED Guidelines. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2013; 54:551-563.
- Kanner AM, Ashman E, Gloss D, et al. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2018; 91:74-81.
- The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. NICE Clinical Guideline [CG137]. January 2012.
- Perucca E, Tomson T. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011; 10:446-456.
