Anti-seizure medications (ASMs) and hyponatremia
Evidence-based neurology checklist on anti-seizure medications (asms) and hyponatremia: AEDS with high risk of hyponatremia Oxcarbezepine: this occurs in 43-36% of cases Eslicarbazepine: this develops in 33% of cases Carbamazepine: this develops in 16-26% of cases AEDS with medium risk of…
AEDS with high risk of hyponatremia
- Oxcarbezepine: this occurs in 43-36% of cases
- Eslicarbazepine: this develops in 33% of cases
- Carbamazepine: this develops in 16-26% of cases
AEDS with medium risk of hyponatremia
AEDS with low risk of hyponatremia
Pathogenesis of hyponatraemia with AEDs
Risk factors for hyponatremia with AEDs
Symptoms of hyponatremia
Precautions with Oxcarbazepine and Carbamazepine
References
- Falhammar H, Lindh JD, Calissendorff J, et al. Differences in associations of antiepileptic drugs and hospitalization due to hyponatremia: a population-based case-control study. Seizure 2018; 59:28-33.
- Berghuis B, van der Palen J, de Haan GJ, Lindhout D, Koeleman BPC, Sander JW; EpiPGX Consortium. Carbamazepine- and oxcarbazepine-induced hyponatremia in people with epilepsy. Epilepsia 2017; 58:1227-1233.
- Lin CH, Lu CH, Wang FJ, et al. Risk factors of oxcarbazepine-induced hyponatremia in patients with epilepsy. Clin Neuropharmacol 2010; 33:293-296.
- Intravooth T, Staack AM, Juerges K, Stockinger J, Steinhoff BJ. Antiepileptic drugs-induced hyponatremia: review and analysis of 560 hospitalized patients. Epilepsy Res 2018; 143:7-10.
- Berghuis B, de Haan GJ, van den Broek MP, Sander JW, Lindhout D, Koeleman BP. Epidemiology, pathophysiology and putative genetic basis of carbamazepine- and oxcarbazepine-induced hyponatremia. Eur J Neurol 2016; 23:1393-1399.
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