Anti IgLON5 antibody syndrome: clinical features
Evidence-based neurology checklist on anti iglon5 antibody syndrome: clinical features: Phenotypes Sleep disorder: parasomnia and sleep-related breathing difficulty Bulbar syndrome Progressive supranuclear palsy (PSP-like) syndrome Cognitive decline: with or without chorea Sleep related…
Phenotypes
- Sleep disorder: parasomnia and sleep-related breathing difficulty
- Bulbar syndrome
- Progressive supranuclear palsy (PSP-like) syndrome
- Cognitive decline: with or without chorea
Sleep related respiratory features
Non-sleep related respiratory features
Sleep related behaviours and movements
Bulbar features
Movement disorders
Dysautonomia
Hyperexcitability
Other presentations
References
- Sabater L, Gaig C, Gelpi E, et al. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol 2014; 13:575-586.
- Schröder JB, Melzer N, Ruck T, et al. Isolated dysphagia as initial sign of anti-IgLON5 syndrome. Neurol Neuroimmunol Neuroinflamm 2016; 4:e302.
- Gaig C, Graus F, Compta Y, et al. Clinical manifestations of the anti-IgLON5 disease. Neurology 2017; 88:1736-1743.
- Honorat JA, Komorowski L, Josephs KA, et al. IgLON5 antibody: Neurological accompaniments and outcomes in 20 patients. Neurol Neuroimmunol Neuroinflamm 2017; 4:e385.
- Gelpi E, Höftberger R, Graus F, et al. Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol 2016; 132:531-543.
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