Anti-Hu antibody paraneoplastic syndrome: clinical features

Evidence-based neurology checklist on anti-hu antibody paraneoplastic syndrome: clinical features: Major syndromes Limbic encephalitis Paraneoplastic encephalitis Paraneoplastic cerebellar degeneration Movement disorders Seizure disorders Ophthalmic features Cranial neuropathies Peripheral…

Major syndromes

  • Limbic encephalitis
  • Paraneoplastic encephalitis
  • Paraneoplastic cerebellar degeneration

Movement disorders

Seizure disorders

Ophthalmic features

Cranial neuropathies

Peripheral neuropathy

Autonomic dysfunction

Other clinical features

Magnetic resonance imaging (MRI) features

References

  1. Rosenbloom MH, Smith S, Akdal G, Geschwind MD. Immunologically mediated dementias. Curr Neurol Neurosci Rep 2009; 9:359-367.
  2. Graus F, Keime-Guibert F, Reñe R, et al. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001; 124:1138-1148.
  3. Hersh B, Dalmau J, Dangond F, Gultekin S, Geller E, Wen PY. Paraneoplastic opsoclonus-myoclonus associated with anti-Hu antibody. Neurology 1994; 44:1754-1755. 
  4. Langer JE, Lopes MB, Fountain NB, et al. An unusual presentation of anti-Hu-associated paraneoplastic limbic encephalitis. Dev Med Child Neurol 2012; 54:863-866.
  5. Schrader C, Alwan G, Weissenborn K. Pseudochoreoathetosis can be the first clinical manifestation of anti-Hu-neuropathy associated with squamous cell carcinoma. Mov Disord 2008; 23:2257-2259.
  6. And 29 more. Subscribe to see the full list

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