Alexander disease: management
Evidence-based neurology checklist on alexander disease: management: Magnetic resonance imaging (MRI): features Contrast enhancing lesions Ventricular garlands Pial signal changes: along the brainstem Eye-spot signs: in the anterior medulla Angel wings appearance: in the middle medulla Atrophy of…
Magnetic resonance imaging (MRI): features
- Contrast enhancing lesions
- Ventricular garlands
- Pial signal changes: along the brainstem
- Eye-spot signs: in the anterior medulla
- Angel wings appearance: in the middle medulla
- Atrophy of medulla and cervical cord
- Ventricular garlands
Magnetic resonance imaging (MRI): sites of enhancing lesions
Cerebrospinal fluid (CSF) analysis
Other investigations
Treatment
References
- Pareyson D, Fancellu R, Mariotti C, et al. Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature. Brain 2008; 131:2321-2331.
- Namekawa M, Takiyama Y, Honda J, Shimakazi H, Sakoe K, Nakano I. Adult-onset Alexander disease with typical "tadpole" brainstorm atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature. BMC Neurology 2010; 10:21.
- Kang YR, Nam TS, Kim JM, et al. Older adult-onset Alexander disease with atypical clinicoradiological features: a case report. Front Neurol 2023; 14:1139047.
- Oliveira DA, Araújo LC, Paiva ARB, Melo ES. Adult-onset Alexander disease with brainstem and cervical cord enhancing lesions. Pract Neurol 2023 (Online ahead of print).
- Gopal N, Gupta V, Williams LN, Sandhu SJS. Teaching NeuroImages: neuroimaging in adult-onset Alexander disease. Neurology 2021; 96:e814-e815.
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