AL amyloidosis neuropathy

Evidence-based neurology checklist on al amyloidosis neuropathy: Demographic features This is a paraproteinaemic neuropathy The mean onset age is 65 years Males account for two-thirds of cases It rapidly progresses from small to large fiber neuropathy Neuropathy presentations Other neurological…

Demographic features

  • This is a paraproteinaemic neuropathy
  • The mean onset age is 65 years
  • Males account for two-thirds of cases
  • It rapidly progresses from small to large fiber neuropathy

Neuropathy presentations

Other neurological presentations

Clinical features

Non-neurological features

Treatment

Investigational treatment

References

  1. Murphy S, Reilly M. Amyloid neuropathies. ACNR 2011; 11:16-19.
  2. Wang AK, Fealey RD, Gehrking TL, Low PA. Patterns of neuropathy and autonomic failure in patients with amyloidosis. Mayo Clin Proc 2008; 83:1226-1230.
  3. Kowalewski-Zietek J, Dawson TP, Damodaron D, Gillmore JD. An unusual cause of carpal tunnel syndrome. Pract Neurol 2011; 11:352-354.
  4. Matsuda M, Gono T, Morita H, Katoh N, Kodaira M, Ikeda S. Peripheral nerve involvement in primary systemic AL amyloidosis: a clinical and electrophysiological study. Eur J Neurol 2011; 18:604-610. 
  5. Thimm A, Carpinteiro A, Oubari S, et al. Prevalence and predictors of neurological manifestations in systemic AL amyloidosis. J Neurol Sci 2022; 440:120341. 
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