Akathisia: treatment

Evidence-based neurology checklist on akathisia: treatment: General treatment Discontinue or reduce the dose of the trigger drug Switching to atypical antipsychotics Propranolol Anticholinergics Other drugs

General treatment

  • Discontinue or reduce the dose of the trigger drug

Switching to atypical antipsychotics

Propranolol

Anticholinergics

Other drugs

References

  1. Rissardo JP, Vora N, Mathew B, Kashyap V, Muhammad S, Caprara ALF. Overview of movement disorders secondary to drugs. Clin Pract 2023; 13:959-976.
  2. Poyurovsky M, Pashinian A, Weizman R, Fuchs C, Weizman A. Low-dose mirtazapine: a new option in the treatment of antipsychotic-induced akathisia. A randomized, double-blind, placebo- and propranolol-controlled trial. Biol Psychiatry 2006; 59:1071-1077.
  3. Musco S, McAllister V, Caudle I. Dopamine-receptor blocking agent-associated akathisia: a summary of current understanding and proposal for a rational approach to treatment. Ther Adv Psychopharmacol 2020; 10:2045125320937575.
  4. Juncal-Ruiz M, Ramirez-Bonilla M, Gomez-Arnau J, et al. Incidence and risk factors of acute akathisia in 493 individuals with first episode non-affective psychosis: a 6-week randomised study of antipsychotic treatment. Psychopharmacology (Berl) 2017; 234:2563-2570.

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