3,4 diaminopyridine (3,4-DAP)

Evidence-based neurology checklist on 3,4 diaminopyridine (3,4-dap): Mechanism of action This is a voltage-dependent potassium channel blocker It increases the pre-synaptic action potential Indications Side effects Indications for 4-DAP Synonym

Mechanism of action

  • This is a voltage-dependent potassium channel blocker
  • It increases the pre-synaptic action potential

Indications

Side effects

Indications for 4-DAP

Synonym

References

  1. Flet L, Polard E, Guillard O, et al. 3,4-Diaminopyridine safety in clinical practice: an observational, retrospective cohort study. J Neurol 2010; 257:937-946.
  2. Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2010; 17:893-902.1
  3. Zhang N, Hong D, Ouyang T, et al. 3,4-diaminopyridine treatment for Lambert-Eaton myasthenic syndrome in adults: a meta-analysis of randomized controlled trials. BMC Neurol. 2021 Sep 25;21(1):371.
  4. Palace J, Wiles CM, Newsom-Davis J. 3,4 diaminopyridine in the treatment of congenital (hereditary) myasthenia. JNNP 1991; 54:1069-1072.
  5. Anlar B, Varli K, Ozdirim E, Ertan M. 3, 4-diaminopyridine in childhood myasthenia: double-blind, placebo-controlled trial. J Child Neurol 1996; 11:458–461.
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